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Friday, July 20, 2012

Ancient Migratory Events in the Middle East-Y Chromosome Variation of Iranians

A very comprehensive new study on Y-Chromosomes in Iran is shedding light on Haplogroup J2 and the origins of its subclade, M530, also known as L24 and defined by the SNP rs35248080.  The study looks at various population groups in Iran and the spread of Y-Chromosomes.  From a J2 persective, M410, L26, M530 (L24), M67 and M92 were studied along with M205 and M241 in Haplogroup J2b.  The results showed an ancient background mainly composed of J2a subclades, along with an influx of M92 from Asia Minor into certain groups in Iran.  Overall Haplogroup J comprised 31.4% of all modern Iranians combined; with J2 making up 22.5% of the population, the overwhelming majority of that being M410+ (J2a).  From the paper:
In particular, the recently described J2a-M530 shows high frequencies in the Zoroastrians of Yazd (17.6%) and Tehran (15.4%), and in Persians of Yazd (17%).  J2a-M47 reaches frequencies higher than 5% in Yazd, Mazandaran, Khuzestan and Fars....Among the different J2a haplogroups, M530 is the most informative as for ancient dispersal events from the Iranian region.  This lineage probably originated in Iran where it displays its highest frequency and variance in Yazd and Mazandaran.

Also of interest in the paper, some ancient deep rooted lineages from IJ-M429 were observed in the Iranian Plateau.  This of course, forms a solid foundation for the theory of the spread of humans from Iran over the course of history into both India, other parts of the Middle East and elsewhere in Europe.  M530 however, showed a curious diffusion from a fairly clear origin in Iran.  While it did spread early to Turkey and the Levant where subcaldes Z387 and L70 (distinguished in part by DYS 391=9) likely arose, the authors report an almost complete absence of M530 from Iraq in table S3 (only 1.3% in Baghdad, 0% in Marsh Arabs).  It is also absent from 4 of 11 regions referenced from Turkey/Asia Minor and almost completely absent from many areas of Europe with the exception of Italy where migrations of M530 subclades Z387+ and L70+ from Anatolia likely occurred.  Was this uneven distribution through the near east the result of  climate, topography or other civilizations?  The paper does not address this issue and the age estimates and theorized spread discussed in the paper do not seem to correlate with the uneven results reported.  Nevertheless, the paper provides invaluable data on Iran; it is the second major paper to address J2a-M530 and provides a window into theY-chromosome makeup of modern day Iran with genetic clues to a very ancient presence of Humans in the country.



Al Aburto said...

Hi David,
My feeling is that the data sampling is still insufficient in many areas. This situation will improve with continued data collection but it may take some time and effort to complete. We know already for example that J2a-M530 (L24) is found throughout Europe: The J-L24(M530)-Y-DNA Project.

Note for example that in Grugni's paper that Spain is shown with 0.00% frequency among Andalusia, Basque, and Catalans, but this is not true at all. Here I am for example an J2a-L24 (M530) Basque person. Unfortunately it seems many of the J2's left Spain (Iberia) but we know find them in the Americas.

m172 said...

Hi Al-I would say that is a correct assumption. The FTDNA set shows that J-L24 or M530 is present in Europe, more often though as L70 and/or Z387 derived. However, my point about absence is in a more general sense. Example-In the J-L24 project you may see ~25 samples from the UK and Ireland representing 5-10% of your data. The sample from FTDNA however is so skewed to results from this area, the 25 M530+ samples are among over 40 thousand results meaning an effective 0% frequency. Contrast that to 17.5% in Yazd Iran from the paper and you have an overall much better picture of M530. You are right about more sampling also. More sampling from within the Middle East and Mediterranean will help our understanding of M530. This paper was a giant leap forward but isn't the last word on M530.

Anonymous said...

M530 is a bit late in J2 evolution, so it's not surprising it's also found in Europe. Perhaps, you should have added that earliest forms, J2* and it's immediate derivative J2a*, as well as a plethora of J2 clades are found throughout Iran. Not to mention R1, R1a, R1b. Iranians certainly have the archeological and cultural history, be originators of these groups. It's really not surprising.

lifeoflyman said...

I'm from Alabama and I have the J2a1h1 Y-DNA Haplogroup (subgroup 70). Not what I was expecting, but it's quite facinating.

On my Fathers side I come from a line of French Huguenot that came to America after being heavily persecuted by the Roman Catholic Church. They migrated from the Isle of Jersey to New York and latter New Jersey. Later migrating to Alabama in in the 70's.

The story goes we come from Norman (Norse) Stock. Our ancestors came to France with Rollo and settled what is now known as Normandy.

From my research my ancestry is entirely European. I'm white as a ghost and quite Ruddy.

Still pretty interesting that my Y-DNA is J2. Thought I would share.